I know it's secret of success of prof buyers, but have you list of common exclude l or include audience interests and job title for your verticals? Something like excludes poorest towns of geo or markets with your vertical.
What I see lately is that running "broad" works the best.
For example ... I have a mature pixel with 1000+ orders and when a I open market, I just target top-level interest (eg. Hunting).
Also, I always run all ages and all cities.
I guess it also depends on the vertical. If you're selling high-ticket product, than probably make sense to target job titles/towns/ZIP code/etc.
Anyway, let's wait what FB masters have to say about this. I believe @stickupkid and @maynzie will chime in. 
I am now getting forced to answer ofcourse ;-). Since we run branded sweeps mainly (supermarket/fashion), we often exclude;
- employees working for the brand
- cities where brand HQ's are located, or certain telephone providers are located
- sometimes likers of a certain telephone provider page (vodafone for example), where our campaigns convert less good on/or advertiser demands to do
When duplicating a winning campaign with the goal to scale on bigger audience: for example from, 30+ women, who like brand X ------> women 30+ only, I often exclude the likers I previously bombed the campaign with. So broad + exclude "brand x likers".
Sometimes we run a certain birthday angle, we target people who are celebrating their birthday within 7 days + INCLUDE their closest friends (so they probably tag the birthday boy/girl)
Thx a lot guys. Both solutions are worked for me) So doesn't matter which way you choose)