I'm running international traffic and hear how important speed is.
Does a CDN work with a tracker (CPVLab) to speed up redirects? Does it matter?
Cdn is usually for static content.
@gosu22 - as iamattila says, a CDN is used to speed up delivery of elements of your landing pages, usually images, CSS and Javascript files. If you're running landing pages, a CDN can help out, depending on the volume of traffic you're sending.
(Although beware - they can also slow your lander down! I recently had a problem with a low-ish traffic site on MaxCDN where the CDN kept hanging the entire page for 10+ seconds. Test, don't assume.)
I'm also a fan of the "just have a server near your geo" approach - it's more reliable and gives more of a speed boost. However, depending on where you're targeting, finding a well-connected server can be a bit of a pain in the ass.
For the multiple servers approach, do you then use a load balancer to reach the same tracker DB if you have both US and local? Or buy multiple licenses?
i.e. Load Balancer->Server1/Server2, and Server1 and Server2 has MySQL two-way replication set up
Nice thinking process there gosu! I am working on something relevant at the moment, juicy details will be revealed in the near future.
@gosu22 - I'm usually using either the STM mobile tracker or my own internal tracking solution (more and more often the latter) so licenses aren't really an issue. I generally just run a local database for each tracker to get speeds as high as possible - extra TCP/IP connections are not your friend 
Got my CDN set up with MaxCDN, it's pretty easy to use!
Eventually will move my tracker to another server and try out STM mobile tracker. Using CPVLab right now